Friday, March 13, 2009
Pixar feature films
Respectful Insolence: The most massive scientific fraud ever?
In what experts are calling one of the largest known cases of academic misconduct, a leading anesthesiology researcher has been accused of falsifying data and other fraud in potentially dozens of published studies.
Scott S. Reuben, MD, of Baystate Medical Center in Springfield, Mass., a pioneer in the area of multimodal analgesia, is said to have fabricated his results in at least 21, and perhaps many more, articles dating back to 1996. The confirmed articles were published in Anesthesiology, Anesthesia and Analgesia, the Journal of Clinical Anesthesia and other titles, which have retracted the papers or will soon do so, according to people familiar with the scandal (see list). The journals stressed that Dr. Reuben's co-authors on those papers have not been accused of wrongdoing.
In addition to allegedly falsifying data, Dr. Reuben seems to have committed publishing forgery. Evan Ekman, MD, an orthopedic surgeon in Columbia, S.C., said his name appeared as a co-author on at least two of the retracted papers, despite his having had no hand in the manuscripts. "My names were forgeries on the documents," Dr. Ekman told Anesthesiology News.
Dr. Reuben has been an extremely active and visible figure in multimodal analgesia, particularly as an advocate for its use in minimally invasive orthopedic and spine procedures. His research has provided support for several mainstays of current anesthetic practice, such as the use of nonsteroidal anti-inflammatory drugs and neuropathic agents instead of opioids and preemptive analgesia. Dr. Reuben has also published and presented data suggesting that multimodal analgesia can significantly improve long-term outcomes for patients.
It's hard to overstate how serious this revelation of scientific fraud is for the field of anesthesiology and medicine. Dr. Reuben was considered a pioneer in his field, and his work is not only widely cited, but serves as the basis for an amount of anesthesia practice that few academic anesthesiologists can lay claim to. The twenty-one papers now retracted represent a body of work that appeared on its surface to be quite impressive. Indeed, these two quotes gives you an idea of just how influential Dr. Reuben was:
All of that is now in question, said Steven L. Shafer, MD, editor-in-chief of Anesthesia and Analgesia, which retracted 10 of Dr. Reuben's articles. "We are left with a large hole in our understanding of this field. There are substantial tendrils from this body of work that reach throughout the discipline of postoperative pain management," Dr. Shafer said. "Those tendrils mean that almost every aspect will need to be carefully thought through. What do we still believe to be true? Do the conclusions hold up to scrutiny?"
Dr. Shafer said that although he still believes "philosophically" in multimodal analgesia, he can no longer be absolutely certain of its benefits without confirmation from future studies.
Newstin - Organizing the News
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Reviews of vacations, hotels, resorts, vacation and travel packages - TripAdvisor
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iShares ETFs - Exchange Traded Funds
Stock-Encyclopedia.com ETF Guide
An ETF (Exchange-Traded Fund) is a form of mutual fund which is freely traded on a stock exchange, in the same way that a company's shares are.
There is no front- or back-end load charge, and the only cost to buy and sell is the standard brokerage charge. Like mutual funds, they also charge an annual maintenance fee, but the annual fee for an ETF is typically much less.
Create Video Playlists and Embed Them Anywhere | Embedr
Embedr is a free service that lets anyone create a custom playlist of videos from the top video sites on the web. Now start building that playlist of your favorite Jean Claude Van Damme movie clips that are spread throughout YouTube, MySpace, Vimeo, DailyMotion and more.
TaggedFrog - Free file and document tagging application
Feel the power of tags.
Based on the convenient drag'n'drop technique, TaggedFrog allows you to organize your files, documents and Web links. Just add objects to the library and tag them with any keywords. That's it. You can forget the file name or where the file is located, but don't worry - the tags will find the file for you.